Signaling by Inhibiting the E3 Ubiquitin Plasmacytoid Dendritic Cell Receptor CD2AP/SHIP1 Complex Positively Regulates
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منابع مشابه
CD2-associated protein regulates plasmacytoid dendritic cell migration, but is dispensable for their development and cytokine production.
Plasmacytoid dendritic cells (pDCs) are a dendritic cell subset that secrete type I IFNs in response to microbial stimuli. The scaffold protein, CD2-associated protein (CD2AP), is a marker of human pDCs as it is highly expressed in this cell type. Recently, in human pDCs, decreased CD2AP expression appeared to enhance the production of type I IFNs via an inhibitory receptor-induced signaling ca...
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تاریخ انتشار 2012